Protein expression in various treatment groups (Apatinib 30 µmol/l and Tripterine 2.5 µmol/l) detected by western blot analysis. (A) Expression of p-Akt, p-ERK, cleaved caspase-3 and Bax in four different groups at 24 h post-treatment. (B) Quantification of different protein expression levels between the four groups at 24 h post-treatment. (C) Expression of p-Akt, p-ERK, cleaved caspase-3 and Bax in four different groups at 48 h post-treatment. (D) Quantification of different protein expression levels between the four groups at 48 h post-treatment. *P<0.05, **P<0.01 and ***P<0.001. Akt, protein kinase B; ERK, extracellular signal-regulated kinase; p-Akt, phosphorylated protein kinase B; p-ERK, phosphorylated extracellular signal-regulated kinase; Bax, B-cell lymphoma-associated X protein.