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. 2018 May 9;16(1):199–210. doi: 10.3892/ol.2018.8678

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Immunohistochemistry for LNα3 in pancreatic ductal adenocarcinoma tissues. (A) Pancreatic tissue is negative for staining. (B) Poorly differentiated adenocarcinoma is positive for staining. Intensity of staining for LNα3 in Poorly differentiated domain is more strongly than moderately differentiated domain. (C) Poorly differentiated adenocarcinoma is strong positive for staining. Proliferative duct is negative for staining. (D) Poorly differentiated pancreatic ductal adenocarcinoma positive for staining. Tumor budding was seen in the invasive fronts. Expression of LNα3 is strong. (E) Perineural invasion is observed in poorly differentiated adenocarcinoma. Strong (high expression) stains for LNα3 is shown in tumor cells. (F) Peripancreatic adipo tissue invasion is observed in adenocarcinoma with squamous metaplasia. Strong (high expression) stains for LNα3 is predominantly expressed in cancer cells contacting the stroma at the edge of cancer nests and weakly stains was detected in the center of cancer nests. Magnification, ×200. LNα3, laminin α3.