Table 2.
Hazard ratios of prostate cancer mortality among patients with post-diagnostic use of cholera vaccine as compared to patients without cholera vaccination
| Crude | Adjusted | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | No. of patients | No. of person-years | No. of deaths | IR | HR | 95% CI | P value | HR | 95% CI | P value | ||
| Post-diagnostic use of cholera vaccine | ||||||||||||
| No | 89,142 | 383,035 | 8622 | 22.5 | Reference | Reference | ||||||
| Yes | 841 | 6033 | 29 | 4.8 | 0.33 | 0.23 | 0.47 | <0.0001 | 0.57 | 0.40 | 0.82 | 0.00 |
| Age at diagnosis | ||||||||||||
| <65 | 445 | 3344 | 9 | 2.7 | 0.45 | 0.23 | 0.86 | 0.02 | 0.57 | 0.30 | 1.11 | 0.09 |
| ≥65 | 396 | 2689 | 20 | 7.4 | 0.36 | 0.23 | 0.56 | <0.0001 | 0.60 | 0.38 | 0.93 | 0.02 |
| Stage at diagnosis | ||||||||||||
| Stages 1 and 2 | 738 | 5365 | 9 | 1.7 | 0.25 | 0.13 | 0.47 | <0.0001 | 0.54 | 0.28 | 1.04 | 0.06 |
| Stages 3 and 4 | 103 | 668 | 20 | 30.0 | 0.51 | 0.33 | 0.79 | 0.00 | 0.62 | 0.40 | 0.97 | 0.03 |
| Income | ||||||||||||
| Lowest | 71 | 499 | 1 | 2.0 | 0.09 | 0.01 | 0.62 | 0.01 | 0.20 | 0.03 | 1.40 | 0.10 |
| Middle-low | 129 | 935 | 2 | 2.1 | 0.12 | 0.03 | 0.46 | 0.01 | 0.20 | 0.05 | 0.82 | 0.02 |
| Middle-high | 213 | 1544 | 7 | 4.5 | 0.40 | 0.19 | 0.85 | 0.02 | 0.54 | 0.26 | 1.13 | 0.10 |
| Highest | 428 | 3055 | 19 | 6.2 | 0.80 | 0.51 | 1.26 | 0.32 | 0.73 | 0.46 | 1.16 | 0.18 |
HR indicates hazard ratio, and it was adjusted by age at diagnosis, year of diagnosis, birth country, highest education level, stage at diagnosis, income, region, chronic ischemic heart disease, chronic obstructive pulmonary disease, diabetes, and hypertension
IR indicates the incidence rate of prostate cancer mortality per 1000 person-years