Table V.
GO enrichments of correlated genes with CXXC5.
| Significant terms | Description | P-value | Associated genes |
|---|---|---|---|
| Biological process | |||
| GO:1902236 | Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 4.53×10−5 | WFS1, TMBIM6, XBP1 |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | 7.14×10−4 | CXXC5, FOXA1, GATA3, WFS1, CCND1, SPDEF, DACH1, XBP1, BCL11A, LPIN1 |
| GO:0009653 | Anatomical structure morphogenesis | 2.25×10−3 | FOXA1, GATA3, KRT18, SOX10 |
| GO:0043627 | Response to estrogen | 2.40×10−3 | GATA3, ESR1, CCND1 |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | 2.64×10−3 | WFS1, ESR1, SIGIRR |
| Cellular component | 9.57×10−4 | ||
| GO:0005902 | Microvillus | 4.59×10−3 | FOXA1, STARD10, SLC9A3R1 |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | 4.53×10−5 | WFS1, PIGT, XBP1 |
| GO:0070062 | Extracellular exosome | 6.21×10−3 | ANXA9, SLC9A3R1, KRT18, TFF3, WWP1, GFRA1, FBP1, MLPH, NME3, CMBL, H2AFJ, HAGH, PVRL2, HSPB1, SERPINA5, TSPAN1, GAMT, PSAT1, PM20D2, FAM171A1, SFT2D2 |
| GO:0071944 | Cell periphery | 7.21×10−3 | SLC9A3R1, KRT18 |
| Molecular function | 1.76×10−4 | ||
| GO:0008134 | Transcription factor binding | 4.10×10−3 | CXXC5, FOXA1, GATA3, ESR1, CCND1, FOXC1, SOX10 |
| GO:0000981 | Sequence-specific DNA binding RNA polymerase II transcription factor activity | 7.43×10−3 | FOXA1, SPDEF, XBP1, FOXC1 |
| GO:0001078 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | 8.49×10−3 | GATA3, DACH1, BCL11A |
| GO:0044212 | Transcription regulatory region DNA binding | 8.49E-03 | FOXA1, GATA3, XBP1, FOXC1 |
GO, gene ontology; CXXC5, CXXC finger protein 5; WFS1, wolframin ER transmembrane glycoprotein; TMBIM6, transmembrane BAX inhibitor motif containing 6; XBP1, X-Box binding protein 1; FOXA1, forkhead Box A1; GATA3, GATA binding protein 3; CCND1, Cyclin D1; SPDEF, SAM pointed domain containing ETS transcription factor; DACH1, dachshund family transcription factor 1; BCL11A, B-cell CLL/lymphoma 11A; LPIN1, Lipin 1; KRT18, keratin 18; SOX10, SRY-box 10; ESR1, estrogen receptor 1; SIGIRR, single Ig and TIR domain containing; STARD10, StAR related lLipid transfer domain containing 10; SLC9A3R1, SLC9A3 regulator 1; PIGT, phosphatidylinositol glycan anchor biosynthesis class T; ANXA9, Annexin A9; TFF3, trefoil factor 3; WWP1, WW domain containing E3 ubiquitin protein ligase 1; GFRA1, GDNF family receptor α1; FBP1, fructose-bisphosphatase 1; MLPH, melanophilin; NME3, NME/NM23 nucleoside diphosphate kinase 3; CMBL, carboxymethylenebutenolidase homolog; H2AFJ, H2A histone family member J; HAGH, hydroxyacylglutathione hydrolase; PVRL2, nectin cell adhesion molecule 2; HSPB1, heat shock protein family B (small) member 1; SERPINA5, serpin family A member 5; TSPAN1, tetraspanin 1; GAMT, guanidinoacetate N-methyltransferase; PSAT1, phosphoserine aminotransferase 1; PM20D2, peptidase M20 domain containing 2; FAM171A1, family with sequence similarity 171 member A1; SFT2D2, SFT2 domain containing 2; FOXC1, forkhead Box C1.