Figure 1.

Computationally predicted TREs in DKK1, a lung cancer-associated gene. (A) A major DHS was identified at the distal DKK1 promoter in 3 cell lines that express the DKK1 gene, including a 100% vert.cons region. (B) Histone modification patterns at the 2 DHSs of the DKK1 gene in A549; the highlighted sequence is the previously identified TRE3. TRE, transcriptional regulatory element; DKK1, dickkopf 1; DHS, DNase I hypersensitive sites; vert.cons, conserved by vertebrates; chr, chromosome; CTCF, CCCTC binding factor; HUVECs, human umbilical vein endothelial cells; NHLF, normal human lung fibroblasts.