Fig. 1. (a) DNA sequences (c-MYC, h-TELO and ds DNA) used in this study, (b) one-pot synthesis of carbazole derivative BTC, (c) FRET melting profiles of c-MYC-(A), h-TELO-(A) and ds DNA with increasing [BTC] in the presence and absence of K+; Tm (°C) for c-MYC-(A) = (69 ± 1), h-TELO-(A) = (55 ± 1), and ds DNA = (57 ± 1). (d) Schematic representations of a G-quadruplex formation by BTC induced folding of a G-rich strand.
