Fig. 3. Monitoring the reaction for intramolecular thiol–yne hydrothiolation in model peptide 1a. (A) HPLC traces of the reaction mixture at different UV irradiation times, monitored at 220 nm; (B) 1H-NMR spectra of 1a, 2a-A and 2a-B (measured in DMSO-d6 at 400 MHz). Asterisks indicate the formation of a vinyl sulfide double bond after UV irradiation.
