Table 1.

Characteristics of patients born in 1970 or later by CAH type and era of birth

	Salt wasting	Simple virilizing
Sample size (N = 194)	124	70
Males (%)	48	46
Birth era (%)
1970–1994	62	80
1994–2013	38	20
BMI measurements per year
Born 1970–1994	2.0 ± 1	2.1 ± 1
Born 1995–2013	3.5 ± 7	2.6 ± 2
Ever oversuppressed	82*	53*
(≥3 of 17 OHP
< 400 ng/dl)† (%)
Height for Age ≥95th percentile at least once (%)
2–5 years old	6*	50*
6–18 years old	10*	51*
Mean hydrocortisone dose‡ (mg/m2/day), born 1970–1994
0–5 years old	15 ± 4**	20 ± 4**
6–18 years old	14 ± 5	16 ± 5
Mean hydrocortisone dose‡ /day), (mg/m2 born 1995–2013
0–5 years old	12 ± 4**	12 ± 4
6–18 years old	9 ± 3	9 ± 4
Mean fludrocortisone‡ (mg)
0–5 years old	0.09 ± 0.03	0.10 ± 0.05
6–18 years old	0.09 ± 0.03	0.09 ± 0.03
Mean relative fludrocortisone‡ (mcg/m2; 95% confidence interval)
0–5 years old	138 (128–148)**	133 (106–166)**
6–18 years old	64 (60–68)	62 (54–73)
Mean plasma renin activity (ng/ml/h; 95% confidence interval)
0–5 years old	1.7 (1–2)***	5.4 (3–9)
6–18 years old	2.8 (2–4)	3.0 (2–4)

Values are number (per cent of sample) or mean ± standard deviation.

^*Rates of SW and SV children were significantly different (P < 0.01).

^**Mean dose in children aged 0–5 significantly higher than in children aged 6–18 within same CAH subtype (P < 0.05).

^***Mean activity in SW children aged 0–5 significantly lower than in SW children aged 6–18 (P = 0.007).

^†Sample restricted to children with at least 3 measurements of 17-OHP; 400 ng/dl of 17OHP = 12.012 nmol/l. (ng/dl × 0.0303 = nmol/l.)

^‡Mean dose for each child calculated for each age interval (0–5, 6–18 years) as area under the curve (sum of the products of dose by time-interval) divided by total dosing interval in those children receiving the drug.