Table 3.
List of functional groups and related liver DEGs from C. semilaevis in response to long-term hypotonic stress
| Function group | Gene name | Gene ID | Gene function | Log2(fold change) |
|---|---|---|---|---|
| Metabolism | ||||
| ebp | XM_008318098.1 | emopamil binding protein (sterol isomerase) | + 3.73 | |
| lss | XM_008328991.1 | lanosterol synthase (2%2C3-oxidosqualene-lanosterol cyclase) | + 3.31 | |
| cyp51 | XM_008331912.1 | lanosterol 14-alpha demethylase | + 3.12 | |
| fdps | XM_008323163.1 | farnesyl diphosphate synthase | + 2.99 | |
| hmgcs1 | XM_008324442.1 | hydroxymethylglutaryl-CoA synthase%2C cytoplasmic-like | + 2.77 | |
| pmvk | XM_008322893.1 | phosphomevalonate kinase | + 2.54 | |
| acat2 | XM_008313119.1 | acetyl-CoA acetyltransferase 2 | + 2.53 | |
| dhcr24 | XM_008307100.1 | 24-dehydrocholesterol reductase | + 2.39 | |
| msmo1 | XM_008317461.1 | methylsterol monooxygenase 1 | + 2.11 | |
| dhcr7 | XM_008309911.1 | 7-dehydrocholesterol reductase | + 1.89 | |
| sc5d | XM_008333068.1 | sterol-C5-desaturase%2C transcript variant X1 | + 1.83 | |
| LOC103396997 | XM_008335243.1 | endothelial lipase-like | + 1.74 | |
| hmgcr | XM_008335608.1 | 3-hydroxy-3-methylglutaryl-CoA reductase | + 1.74 | |
| mvk | XM_008335531.1 | mevalonate kinase | + 1.54 | |
| LOC103397733 | XM_008336101.1 | endothelial lipase-like | + 1.54 | |
| idh1 | XM_008327862.1 | isocitrate dehydrogenase 1 (NADP+)%2C soluble | + 1.48 | |
| LOC103395808 | XM_008333603.1 | 3-keto-steroid reductase-like | + 1.45 | |
| abat | XM_008330509.1 | 4-aminobutyrate aminotransferase | −2.54 | |
| acy1 | XM_008319784.1 | aminoacylase 1 | −1.87 | |
| ddc | XM_008323903.1 | dopa decarboxylase (aromatic L-amino acid decarboxylase) | − 1.82 | |
| LOC103377813 | XM_008308777.1 | alkaline phosphatase-like | −1.79 | |
| LOC103389307 | XM_008324669.1 | bile salt-activated lipase-like | −1.73 | |
| LOC103388276 | XM_008323191.1 | pyruvate kinase PKM-like | −1.72 | |
| LOC103389284 | XM_008324640.1 | bile salt-activated lipase-like | −1.69 | |
| LOC103378976 | XM_008310359.1 | phospholipase D1-like | −1.66 | |
| gamt | XM_008333805.1 | guanidinoacetate N-methyltransferase | −1.64 | |
| LOC103387723 | XM_008322480.1 | inactive pancreatic lipase-related protein 1-like | −1.62 | |
| LOC103399583 | XM_008338252.1 | aminoacylase-1-like | −1.61 | |
| LOC103392251 | XM_008328834.1 | uricase-like | −1.58 | |
| LOC103396493 | XM_008334595.1 | pancreatic alpha-amylase-like | −1.54 | |
| LOC103390352 | XM_008326174.1 | UDP-glucuronosyltransferase 2A1-like%2C transcript variant X3 | −1.31 | |
| LOC103381542 | XM_008313955.1 | neutral alpha-glucosidase C-like | −1.20 | |
| Osmoregulation and ion transport | ||||
| LOC103392748 | XM_008329462.1 | chromodomain-helicase-DNA-binding protein 1-like | + 1.95 | |
| LOC103394918 | XM_008332394.1 | sodium-dependent dopamine transporter-like | + 1.38 | |
| slc6a6 | XM_008319443.1 | solute carrier family 6 (neurotransmitter transporter)%2C member 6%2C transcript variant X1 | −1.95 | |
| rem2 | XM_008334215.1 | RAS (RAD and GEM)-like GTP binding 2 | −1.65 | |
| aqp10 | XM_008323103.1 | aquaporin 10 | −1.58 | |
| LOC103391201 | XM_008327377.1 | ependymin-like | −1.43 | |
| ankh | XM_008308224.1 | ANKH inorganic pyrophosphate transport regulator | −1.33 | |
| LOC103389703 | XM_008325232.1 | sodium- and chloride-dependent GABA transporter 2-like | −1.06 | |
| Signal transduction | ||||
| LOC103385696 | XM_008319660.1 | taste receptor type 1 member 3 | + 2.43 | |
| ghsr | XM_008310310.1 | growth hormone secretagogue receptor | + 2.29 | |
| hmgcr | XM_008335608.1 | 3-hydroxy-3-methylglutaryl-CoA reductase | + 1.74 | |
| LOC103398491 | XM_008337141.1 | cocaine- and amphetamine-regulated transcript protein-like | + 1.72 | |
| LOC103395241 | XM_008332898.1 | olfactory receptor 24-like | −2.94 | |
| abat | XM_008330509.1 | 4-aminobutyrate aminotransferase | −2.54 | |
| LOC103390650 | XM_008326578.1 | ankyrin repeat and SOCS box protein 5-like | −2.03 | |
| LOC103393547 | XM_008330546.1 | TANK-binding kinase 1-binding protein 1-like | −1.86 | |
| LOC103383485 | XM_008316623.1 | ATP-binding cassette sub-family G member 2-like | −1.81 | |
| LOC103378821 | XM_008310167.1 | galanin receptor type 1-like | −1.78 | |
| LOC103381198 | XM_008313433.1 | scavenger receptor class A member 3-like | −1.75 | |
| rem2 | XM_008334215.1 | RAS (RAD and GEM)-like GTP binding 2 | −1.65 | |
| LOC103388851 | XM_008324050.1 | C-X-C chemokine receptor type 3-like | −1.64 | |
| dpf3 | XM_008312830.1 | D4%2C zinc and double PHD fingers%2C family 3%2C transcript variant X3 | −1.60 | |
| LOC103392251 | XM_008328834.1 | uricase-like | −1.58 | |
| LOC103396858 | XM_008335106.1 | zinc finger protein 79-like | −1.54 | |
| npr1 | XM_008330816.1 | natriuretic peptide receptor 1 | −1.44 | |
| LOC103391201 | XM_008327377.1 | ependymin-like | −1.43 | |
| LOC103398008 | XM_008336483.1 | phosphatidylinositol 3-kinase regulatory subunit alpha-like%2C transcript variant X1 | −1.35 | |
| Immune response and stress response | ||||
| ebp | XM_008318098.1 | emopamil binding protein (sterol isomerase) | + 3.73 | |
| LOC103385685 | XM_008319650.1 | coiled-coil domain-containing protein 114-like | + 2.20 | |
| LOC103398491 | XM_008337141.1 | cocaine- and amphetamine-regulated transcript protein-like | + 1.72 | |
| endou | XM_008320007.1 | endonuclease%2C polyU-specific | −2.03 | |
| LOC103393547 | XM_008330546.1 | TANK-binding kinase 1-binding protein 1-like | −1.86 | |
| LOC103381198 | XM_008313433.1 | scavenger receptor class A member 3-like | −1.75 | |
| LOC103388276 | XM_008323191.1 | pyruvate kinase PKM-like | −1.72 | |
| fam163b | XM_008324326.1 | family with sequence similarity 163%2C member B | −1.54 | |
| Cytoskeleton remodeling | ||||
| srebf2 | XM_008330306.1 | sterol regulatory element binding transcription factor 2 | + 1.42 | |
| ablim3 | XM_008327647.1 | actin binding LIM protein family%2C member 3 | −1.88 | |
| LOC103393547 | XM_008330546.1 | TANK-binding kinase 1-binding protein 1-like | −1.86 | |
| LOC103381198 | XM_008313433.1 | scavenger receptor class A member 3-like | −1.75 | |
| LOC103398008 | XM_008336483.1 | phosphatidylinositol 3-kinase regulatory subunit alpha-like%2C transcript variant X1 | −1.35 | |