Table 2.
Relationships between the HOXA11 level and clinicopathological parameters in LUSC based on the TCGA database
| Clinicopathological parameters | n | Relevant expression of HOXA11 (2-ΔCq) | |||
|---|---|---|---|---|---|
| Mean ± SD | t | P value | |||
| Tissue | Adjacent non-cancerous lung tissue | 18 | 1.209 ± 0.813 | − 20.240a | 1.5855E−17 |
| Cancer | 475 | 5.531 ± 2.054 | |||
| Age (years) | < 60 | 41 | 5.578 ± 2.374 | 0.087a | 0.931 |
| ≥ 60 | 199 | 5.609 ± 2.080 | |||
| Gender | Male | 353 | 5.593 ± 2.049 | 1.123a | 0.262 |
| Female | 120 | 5.349 ± 2.065 | |||
| Status | Dead | 204 | 5.445 ± 2.003 | − 0.799a | 0.425 |
| Alive | 269 | 5.597 ± 2.093 | |||
| Neoplasm cancer status | With tumor | 108 | 5.335 ± 2.211 | − 1.086a | 0.278 |
| Tumor-free | 299 | 5.590 ± 2.037 | |||
| M | M0 | 390 | 5.549 ± 2.069 | F = 0.224b | 0.800 |
| M1 | 4 | 6.041 ± 2.528 | |||
| MX | 73 | 5.431 ± 1.974 | |||
| T | T1–T2 | 385 | 5.526 ± 2.029 | − 0.119a | 0.906 |
| T3–T4 | 88 | 5.555 ± 2.172 | |||
| N | N0–N1 | 424 | 5.525 ± 2.050 | F = 2.565b | 0.078 |
| N2–N3 | 45 | 5.780 ± 1.974 | |||
| NX | 4 | 3.369 ± 2.596 | |||
| Race | White | 331 | 5.465 ± 2.051 | F = 3.892b | 0.021* |
| Asian | 9 | 4.264 ± 2.662 | |||
| Black | 28 | 6.304 ± 1.585 | |||
| Recurrence | Distant metastasis | 36 | 5.524 ± 2.346 | F = 0.565b | 0.571 |
| New primary tumor | 12 | 5.457 ± 2.031 | |||
| Locoregional recurrence | 30 | 4.959 ± 2.135 | |||
*P < 0.05 was considered statistically significant
aStudent’s paired or unpaired t test was used for comparison between two groups
bOne-way analysis of variance (ANOVA) was performed