Table 2.
Bivariate analysis to demonstrate the differences between the groups according to SMD quantification by the Fazekas, Scheltens (hippocampal atrophy), and Koedam (parietal atrophy) scales on MRI
| Classification | NC, n (%) (n = 34) | MCI, n (%) (n = 41) | AD, n (%) (n = 30) | p | |
|---|---|---|---|---|---|
| Fazekas scaleA, B, C | 0 | 16 (47.1) | 6 (14.6) | 2 (6.7) | <0.001 |
| 1 | 15 (44.1) | 28 (68.3) | 6 (20) | ||
| 2 | 3 (8.8) | 7 (17.3) | 22 (73) | ||
| 3 | 0 | 0 | 0 | ||
| Scheltens scaleA, B, C | 0 | 21 (61.8) | 18 (43.9 | 0 | <0.001 |
| 1 | 11 (3.4) | 15 (36.6) | 5 (16.7) | ||
| 2 | 2 (5.9) | 7 (17.1) | 13 (43.4) | ||
| 3 | 0 | 1 (2.4) | 10 (33.3) | ||
| 4 | 0 | 0 | 2 (6.0) | ||
| Koedam scaleA, B, C | 0 | 17 (50) | 13 (31.7) | 0 | <0.001 |
| 1 | 16 (47.1) | 22 (53.7) | 22 (73.3) | ||
| 2 | 1 (2.9) | 6 (14.6) | 7 (23.3) | ||
| 3 | 0 | 0 | 1 (3.3) | ||
| Lobar microbleedsA, B | Presence | 0 | 1 (2.4) | 6 (20) | 0.002 |
| Absence | 34 (100) | 40 (97.6) | 24 (80) | ||
SMD, small-vessel disease; MRI, magnetic resonance imaging; NC, normal cognition; MCI, mild cognitive impairment; AD, Alzheimer disease.
A
Post-hoc Bonferroni analysis: AD versus NC, p < 0.05
B
Post-hoc Bonferroni analysis: AD versus MCI, p < 0.05
C
Post-hoc Bonferroni analysis: MCI versus NC, p < 0.05.