Table 5.

Quality assessment of included studies

Validity	Quality criteria	Study
		Alissa et al., 2010 [15]	Farina et al., 2013 [21]	Suttapreyasri and Leepong 2013 [17]	Hauser et al. 2013 [18]	Anitua et al. 2015 [16]	Marenzi et al. 2015 [19]	Temmerman et al. 2016 [20]
External	declared use specific protocol guidelines	yes	NR	NR	NR	yes	NR	NR
	representative population group	yes	yes	yes	yes	yes	yes	yes
	eligibility criteria defined	yes	yes	yes	yes	yes	NR	yes
Internal	consecutive enrollment	NR	NR	NR	NR	NR	NR	NR
	random allocation	yes	NA	yes	yes	yes	yes	yes
	allocation concealment	yes	NA	NR	NR	yes	NR	yes
	blinding of the patient	NR	no	NR	NR	NR	NR	NR
	blinding of the examiner	yes	yes	NR	yes	yes	NR	NR
	blinding of the statistician	NR	NR	NR	NR	NR	NR	NR
	reported loss to follow-up	yes	yes	NR	yes	yes	yes	yes
	no. (%) of dropouts	7 (30.4%)	0	0	1 (4.34%)	8 (13%)	0	0
	treatment identical, except for intervention	yes	yes	yes	yes	yes	yes	yes
Statistical	sample size calculation and power	yes§	NR	NR	NR	yes	NR	yes
	point estimates presented for primary outcome	yes	yes	yes	yes	yes	yes	yes
	measures of variability for the primary outcome	yes	yes	yes	yes	yes	yes	yes
	intention to treat analysis	yes	NR	NR	NR	NR	NR	NR
	coherent data presentation	yes	yes	no	no	yes	no	yes
Clinical aspects	study design#	RCT parallel	CCT parallel	RCT split-mouth	RCT parallel	RCT parallel	RCT split-mouth	RCT split-mouth
	validated measurement	NR	NR	NR	NR	NR	NR	NR
	calibration of examiner	yes	yes	NR	NR	NR	NR	NR
	estimated potential risk of bias	low	moderate	high	high	low	high	moderate

NR = Not reported; NA = not applicable; RCT = randomized clinical trial; CCT = controlled clinical trial-°Relevant if >20%.

^§Calculated sample size not reached.

^#Higher risk of bias for RCT versus CCT.