Table 2.

Core pathways and their associated genes found

GOID	GOTerm	Term P value	% associated genes	Associated genes found
GO:0004915	Estrogen signaling pathway	130.0E−3	6.12	[CALM3, CALML4, HSPA1L, HSPA8, ITPR3, MAPK3]
GO:0004390	Hippo signaling pathway	62.0E−3	5.84	[ACTG1, APC2, BIRC2, BMP2, FRMD6, LLGL2, RASSF6, SOX2, WNT8A]
GO:0004520	Adherens junction	290.0E−3	5.56	[ACTG1, MAPK3, PTPRM, WAS]
GO:0004657	IL-17 signaling pathway	220.0E−3	5.38	[IL6, MAPK15, MAPK3, S100A8, S100A9]
GO:0004621	NOD-like receptor signaling pathway	110.0E−3	5.29	[BIRC2, ERBIN, IFNA1, IFNAR2, IL6, ITPR3, MAPK3, RNASEL, TP53BP1]
GO:0004210	Apoptosis	210.0E−3	5.07	[ACTG1, BIRC2, ITPR3, LMNA, MAPK3, PDPK1, TUBA3D]
GO:0004371	Apelin signaling pathway	210.0E−3	5.07	[CALM3, CALML4, GNG11, ITPR3, MAPK3, PRKAG2, RYR2]
GO:0004722	Neurotrophin signaling pathway	270.0E−3	5.04	[CALM3, CALML4, IRAK2, MAGED1, MAPK3, PDPK1]
GO:0004020	Calcium signaling pathway	190.0E−3	4.95	[CALM3, CALML4, CHRM3, ITPR3, P2RX2, PTGER3, RYR2, SLC25A4, STIM2]
GO:0004512	ECM–receptor interaction	330.0E−3	4.88	[COL1A2, COL2A1, COL6A1, HSPG2]
GO:0004620	Toll-like receptor signaling pathway	380.0E−3	4.81	[IFNA1, IFNAR2, IL6, MAP2K3, MAPK3]
GO:0004150	mTOR signaling pathway	340.0E−3	4.61	[ATP6V1B2, DEPDC5, EIF4E, MAPK3, PDPK1, PRR5, WNT8A]
GO:0004068	FoxO signaling pathway	310.0E−3	4.55	[BCL6, CCNG2, IL6, MAPK3, PDPK1, PRKAG2]
GO:0004510	Focal adhesion	290.0E−3	4.52	[ACTG1, BCAR1, BIRC2, COL1A2, COL2A1, COL6A1, MAPK3, PARVB, PDPK1]
GO:0004514	Cell adhesion molecules (CAMs)	460.0E−3	4.14	[CADM1, CLDN5, NCAM2, PTPRC, PTPRM, SELP]