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. 2018 Jun 19;6:58. doi: 10.1186/s40425-018-0357-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Sebaceous carcinoma: Sheets of malignant cells are shown invading subcutaneous adipose tissue along with tumor infiltrating lymphocytes (lower right) (a). Malignant epithelial cells with nuclear pleomorphism, coarse chromatin, prominent nucleoli and increased mitotic activity (b). Carcinoma with stromal desmoplasia and tumor necrosis (c). Intracytoplasmic vacuolations suggest sebaceous differentiation (d). Carcinoma exhibiting lymphovascular space invasion (e). Adipophilin immunohistochemistry demonstrating diffuse (f) and characteristic strong membranous staining of the intracytoplasmic lipid vacuoles (g). PD-L1 (22C3, pharm Dx) immunohistochemistry showing positive (high, tumor proportion score > 50%) expression in 100% of tumor cells (h)