Table 1.

HDACi IC₅₀ on immune cells

	Lymphocytes		T-CD8 clones
	− Decitabine	+ Decitabine 500 nM	− Decitabine	+ Decitabine 500 nM
VPA	6.75 ± 0.06 mM	3.05 ± 0.11 mM	3.80 ± 0.06 mM	0.02 ± 0.10 mM
SAHA	13.66 ± 0.05 μM	9.9 ± 0.08 μM	1.29 ± 0.05 μM	0.08 ± 0.06 μM
ODB	ND	ND	28.81 ± 0.05 μM	0.17 ± 0.12 μM
NODB	46.01 ± 0.06 μM	26.22 ± 0.05 μM	17.99 ± 0.05 μM	0.37 ± 0.12 μM
ODH	9.62 ± 0.05 μM	5.28 ± 0.09 μM	1.86 ± 0.05 μM	0.07 ± 0.07 μM
NODH	0.43 ± 0.06 μM	0.19 ± 0.11 μM	0.03 ± 0.05 μM	0.002 ± 0.06 μM

IC₅₀ values were determined using GraphPad prism, Prism 6 for Windows, by curve fitting using a sigmoidal dose response model. Results are the means ± S.E.M of three independent experiments