Table 1.

GSEA analysis of microarray data from macrophages from PTP1B WT and PTP1B KO mice exposed to 5 Gy irradiation. Cells from 4 independent animals for each condition were maintained in culture for 24 h and after analysis of the RNA quality in a Bioanalyzer, equal amounts of RNA were pooled and submitted to microarray hybridization. Gene Set Enrichment Analysis (GSEA) was performed and the quantitative parameters of the significant pathways (FDR < 0.25) are provided. Results show the data from two independent experiments as reflected in Supplementary Fig. S1.

Pathway	Enrichment score	Normal p-value	FDR q-value
Upregulated
Protein secretion	0.374	0.0106	0.2331
TGF-β signaling	0.418	0.0191	0.1216
Angiogenesis	0.442	0.0445	0.1124
Androgen receptor	0.336	0.0720	0.2194
Wnt/β-Catenin	0.386	0.1013	0.2093
IFN-α response	0.316	0.0972	0.2385
Peroxisome	0.309	0.1037	0.2257
IL-6/Jak/Stat-3	0.308	0.1507	0.2338
Downregulated
Myc targets	− 0.436	0.0111	0.0434
Hedgehog signaling	− 0.443	0.0482	0.0746