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. 2018 Jun 12;9:310. doi: 10.3389/fendo.2018.00310

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Copyright © 2018 Mense, Heidekorn-Dettmer, Wirthgen, Brockelmann, Bortfeldt, Peter, Jung, Höflich, Hoeflich and Schmicke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study trial I: insulin-like growth factor-binding protein (IGFBP) (A): -2, (B): -3 and (C): -4 concentration and (D): IGFBP-3/IGFBP-2 ratio in not-pregnant [np, n = 43, day of AI (0) and 18 days after AI] and pregnant (p, n = 34, day of AI, and 18, 42, 60 and 100 days after AI) pluriparous Holstein–Friesian cows as well as cows with fetal mortality (fm, n = 4, day of AI and until day 60 after AI). Values are given in% relative to day 0 of non-pregnant cows. Values are given as mean ± SEM.