Effect of chelerythrine and losartan on ischaemic contracture and LDH activity in APC and IPC/APC treated rat hearts. (A) Ischaemic contracture during global ischaemia. (B) LDH activity in cardiac effluents collected at 5 minutes after the initiation of reperfusion. The values shown are means ± SEM of 5-12 experiments per group. #P <.05, ##P <.01 vs A; &P <.01, &&P <.001 vs IA; @P <.01 vs A+L. A, APC; A+C, APC+chelerythrine; A+L, APC+losartan; IA, IPC/APC; IA+C, IPC/APC+chelerythrine; IA+L, IPC/APC+losartan. The number of experiments per group (in parenthesis): A (12), IA (10), A+C (6), IA+C (5), A+L (5), IA+L (7)