Table II.

Enriched GO categories of differentially expressed genes.

A, Biological process clustering
GO term	Biological process	Gene count	Genes	P-value
GO:0006508	Proteolysis	11	CPA1, CPA2, CPB1, CTRC, CELA2A, CELA2B, CELA3A, CELA3B, CTRB2, MMP11, PRSS1	1.7E-09
GO:0007586	Digestion	4	CELA3A, CTRB2, CLPS, PRSS1	1.2E-04
GO:0044241	Lipid digestion	3	CEL, CLPS, PNLIP	1.8E-04
GO:0022617	Extracellular matrix	4	CTRB2, LAMC2, MMP11, PRSS1	2.1E-04
GO:0016042	Lipid catabolic process	4	CLPS, PNLIPRP1, PNLIP, PLA2G1B	3.0E-04
GO:0009235	Cobalamin metabolic process	3	CTRC, CTRB2, PRSS1	4.8E-04
GO:0030299	Intestinal cholesterol absorption	2	CEL, PNLIP	1.4E-02
GO:0006629	Lipid metabolic process	3	CEL, CLPS, PNLIPRP1	2.4E-02
GO:0007093	Mitotic cell cycle checkpoint	2	BUB1B, CHEK1	4.8E-02
GO:0001523	Retinoid metabolic process	2	CLPS, PNLIP	9.0E-02
B, Cellular component
GO term	Biological process	Gene count	Genes	P-value
GO:0005615	Extracellular space	14	CEL, CPA1, CPA2, CPB1, CHEK1, CELA2A, CELA2B, CELA3A, CELA3B, CTRB2, CST2, LAMC2, PNLIPRP1, PLA2G1B	4.1E-08
GO:0005576	Extracellular region	13	CEL, CPA2, CTRC, CELA2B, CTRB2, CLPS, FNDC1, LAMC2, MMP11, PNLIPRP1, PNLIP, PLA2G1B, PRSS1	2.7E-06
GO:0051233	Spindle midzone	2	BUB1B, CDCA8	3.0E-02
C, Molecular function
GO term	Biological process	Gene count	Genes	P-value
GO:0004252	Serine-type endopeptidase activity	8	CTRC, CELA2A, CELA2B, CELA3A, CELA3B, CTRB2, MMP11, PRSS1	1.1E-07
GO:0004806	Triglyceride lipase activity	3	CEL, PNLIPRP1, PNLIP	3.3E-04
GO:0004181	Metal carboxypeptidase activity	3	CPA1, CPA2, CPB1	8.4E-04
GO:0016298	Lipase activity	2	CEL, PNLIPRP1	1.4E-02
GO:0004180	Carboxypeptidase activity	2	CPA2, CPB1	2.7E-02
GO:0008236	Serine-type peptidase activity	2	CTRB2, PRSS1	9.6E-02

GO, gene ontology.