Table V.

Categories of the US Food and Drug Administration-approved drugs associated with upregulated genes.

Category	Drug name
Alkylating agent	Melphalan, temozolomide, busalfan, carmustine, mechlorethamine, cyclophosphamide, busalfan
Hormone agent	Tamoxifen, fulvestrant, bicalutamide
Cytotoxic alkaloid	Etoposide, irinotecan, vinblastine, docetaxel, paclitaxel
Antitumor antibiotic	Doxorubicin, daunorubicin, mitomycin
Antimetabolite	Methotrexate, 5-fluorouracil, clofarabine, gemcitabine, cytarabine, azacitidine, fludarabine, decitabine, hydroxyurea
Protein inhibitor	Vorinostat, bosutinib, sunitinib, bortezomib, olaparib