Table 2.
Secondary metabolite biosynthesis gene clusters identified in the genome of Streptomyces sp. Go-475 with antiSMASH 4.02 (manually curated).
| No | Cluster type | Presence in another bacterium | Putative product |
|---|---|---|---|
| 1 | PKSI-NRPS | Streptomyces olindensis DAUFPE 5622 | Glycosylated PK-NRS peptide hybrid |
| 2 | Melanin | Multiple Streptomyces spp. | Melanin |
| 3 | Nrps | Streptomyces olindensis DAUFPE 5622 | NRS peptide |
| 4 | Unknown | Streptomyces olindensis DAUFPE 5622 | Amino acid-based product |
| 5 | Terpene | Streptomyces olindensis DAUFPE 5622 | Putative sesquiterpene |
| 6 | Lantipeptide | Streptomyces viridochromogenes DSM 40736 | SapB/AmfS family lantipeptide |
| 7 | PKSIII | Streptomyces sp. XY006 | 1,3,6,8-tetrahydroxynaphthalene |
| 8 | Lassopeptide | Streptomyces olindensis DAUFPE 5622 | Lassopeptide |
| 9 | Ectoine | Streptomyces olindensis DAUFPE 5622 | Ectoine, betaine |
| 10 | Terpene | Streptomyces olindensis DAUFPE 5622 | Putative isoprenoid |
| 11 | PKSI-NRPS | Streptomyces chartreusis NRRL 12338 | PK-NRS peptide hybrid |
| 12 | NRPS | Streptomyces olindensis DAUFPE 5622 | Glycosylated NRS peptide |
| 13 | Terpene | Streptomyces olindensis DAUFPE 5622 | Isoprenoid |
| 14 | Melanin | Streptomyces sp. S10(2016) | Melanin |
| 15 | Lassopeptide | Streptomyces chartreusis NRRL 12338 | Lassopeptide |
| 16 | Siderophore | Multiple Streptomyces spp. | Desferrioxamine B |
| 17 | Butyrolactone | Streptomyces olindensis DAUFPE 5622 | Butyrolactone |
| 18 | PKSI-NRPS | Streptomyces olindensis DAUFPE 5622 | PK-NRS peptide hybrid |
| 19 | Phosphonate | Streptomyces olindensis DAUFPE 5622 | Phosphonate metabolite |
| 20 | Terpene | – | Terpenoid |
| 21 | Aminocyclitol | Streptomyces olindensis DAUFPE 5622 | Aminocyclitol |
| 22 | NRPS | Streptomyces vitaminophilus DSM 41686 | NRS peptide |
| 23 | PKSII | Streptomyces olindensis DAUFPE 5622 | Cosmomycins |
| 24 | Terpene | Streptomyces olindensis DAUFPE 5622 | Albaflavenone |
| 25 | Terpene | – | Terpenoid (polyprenyl) |
| 26 | Siderophore | Streptomyces olindensis DAUFPE 5622 | Siderophore |
| 27 | Bacteriocin | Streptomyces olindensis DAUFPE 5622 | Bacteriocin |
| 28 | Terpene | Multiple Streptomyces spp. | Geosmin |
| 29 | PKSI-NRPS | Streptomyces africanus DSM 41829 | PK-NRS peptide hybrid |
| 30 | Siderophore | Streptomyces olindensis DAUFPE 5622 | Siderophore |
| 31 | PKSII | – | Angucyclines |
| 32 | Terpene | Streptomyces olindensis DAUFPE 5622 | Hopanoids |
| 33 | PKSI | Streptomyces olindensis DAUFPE 5622 | PK |
| 34 | Bacteriocin | Multiple Streptomyces spp. | Bacteriocin |
| 35 | Lantipeptide | Multiple Streptomyces spp. | SapB/AmfS family lantipeptide |
| 36 | PKSI | Streptomyces olindensis DAUFPE 5622 | PK |
NRS, non-ribosomally synthesized; PK, polyketide. Shaded cells show gene clusters not present in the genome of S. olindensis DAUPFE 5622. Products in bold text are inferred with certainty based on >90% identity of the gene products to those of the verified gene clusters or experimental data (e.g., angucyclines).