Fig. 5.

Molecular signatures of platelet activation inP. vivaxinfection.A, Heat map of BTMs’ activity for each P. vivax infected subject, included in BTM cluster 8 (Platelet, complement activation) identified by integrative metabolomics and transcriptomics as described in Fig. 4B. B, Boxplots of platelet activation genes PECAM1, SIRPA, SERPINA1 expression assayed by RNA-seq. C, Platelet counts from whole blood at baseline and diagnosis time points. Significance levels are shown as * , p < 0.05; **, p < 0.01. D, Highlighted associations between metabolites and gene cluster 8, as described in Fig. 4B. E, Metabolite clusters associated with gene cluster 8 exemplified as heatmaps. F, Venn diagram showing common m/z peaks detected in platelets derived from healthy donors and plasma metabolite clusters associated with gene cluster 8. G, Metabolite cluster m/z peak over-representation in platelet-enriched metabolites.