Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 15;10:1543–1551. doi: 10.2147/CMAR.S163747

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Čeponytė et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

The effect of NSAIDs on the viability of BxPC-3 and MIA PaCa-2 cells.

Notes: The most potent COX inhibitor meclofenamic acid showed the highest antiproliferative activity on both BxPC-3 and MIA PaCa-2 cell line (EC₅₀ values after 72 h of drug exposure were 16,0 μM for BxPC-3 and, 43,5 μM for MIA PaCa-2 cells). The rank order of the activity of tested NSAIDs on BxPC-3 cell viability was as follows: meclofenamic acid>celecoxib>mefenamic acid>parecoxib>niflumic acid; on MIA PaCa-2 cell viability: meclofenamic acid>parecoxib>celecoxib>mefenamic acid=niflumic acid. Acetylsalicylic acid and salicylic acid had no effect on the viability of cancer cells (data not shown). The asterisks (*) indicate p<0.05.

Abbreviations: EC₅₀, half maximal effective concentration; NSAIDs, non-steroidal anti-inflammatory drugs.