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. 2018 Jun 15;10:1543–1551. doi: 10.2147/CMAR.S163747

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© 2018 Čeponytė et al. This work is published and licensed by Dove Medical Press Limited

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The changes in cell viability after 24, 48, and 72 h of incubation with fenamates and coxibs.

Notes: Salicylates had no effect on viability of both pancreatic cell lines at tested concentrations (up to 500 μM). Fenamates and coxibs exerted time-dependent anti-proliferative effect, though EC₅₀ values against MIA Paca-2 cell line were more consistent after 24 and 72 h compared to BxPC-3 cell line, especially for niflumic acid, meclofenamic acid and celecoxib (p>0.05).

Abbreviation: EC₅₀, half maximal effective concentration.