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. 2018 Jun 15;10:1543–1551. doi: 10.2147/CMAR.S163747

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© 2018 Čeponytė et al. This work is published and licensed by Dove Medical Press Limited

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Apoptosis and necrosis by NSAIDs in BxPC-3 and MIA PaCa-2 cell lines.

Notes: BxPC-3 and MIA PaCa-2 cells after incubation with meclofenamic acid (1, viable cells; 2, apoptotic cells; and 3, necrotic cells); cells were stained with Hoechst 33342 and propidium iodide; magnification 100× (A). Effect of NSAIDs on apoptosis of BxPC-3 cells (B). Effect of NSAIDs on apoptosis of MIA PaCa-2 cells (C). The percentage of necrotic cells in BxPC-3 cell line (D). The percentage of necrotic cells in MIA PaCa-2 cell line (E). The asterisks (*) indicate p<0.05.

Abbreviations: EC₅₀, half maximal effective concentration; NSAIDs, non-steroidal anti-inflammatory drugs.