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. 2018 Jun 15;11:3461–3473. doi: 10.2147/OTT.S164131

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© 2018 Chang et al. This work is published and licensed by Dove Medical Press Limited

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MiR-1 downregulation partly abolished MALAT1 silencing-mediated antiproliferative, antimigratory and proapoptotic effects in PC cells.

Notes: DU145 and PC3 cells were transfected with si-NC, si-MALAT1, si-MALAT1+anti-miR-NC, and si-MALAT1+anti-miR-1, following the determination of miR-1 expression (A), colony formation numbers (B), cell viability (C), cell migration capacity (D), apoptotic rate (E), and protein expressions of cleaved PARP, cleaved caspase-3, BAX, and Bcl-2 (F). *P<0.05.

Abbreviations: MALAT1, metastasis-associated lung adenocarcinoma transcript 1; miR-1, microRNA-1; miR-NC, MiR-1 mimic and its scramble control; PARP, poly (ADP-ribose) polymerase; PC, prostate cancer; si-NC, scramble control.