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. 2018 Jun 15;11:3461–3473. doi: 10.2147/OTT.S164131

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© 2018 Chang et al. This work is published and licensed by Dove Medical Press Limited

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KRAS overexpression weakened miR-1-mediated antiproliferative, antimigratory and proapoptotic effects in PC cells.

Notes: DU145 and PC3 cells were transfected with miR-NC, miR-1, miR-1+pcDNA3.1 vector, and miR-1+pcDNA-KRAS, followed by the determination of KRAS protein expression (A), colony formation numbers (B), cell viability (C), cell migration capacity (D), apoptotic rate (E), and protein expressions of cleaved PARP, cleaved caspase-3, BAX, and Bcl-2 (F). *P<0.05.

Abbreviations: MALAT1, metastasis-associated lung adenocarcinoma transcript 1; miR-1, microRNA-1; miR-NC, miR-1 mimic and its scramble control; PARP, poly (ADP-ribose) polymerase; PC, prostate cancer.