Table 1.
Baseline | After RT | True Progression | Last Visit | ||||||
---|---|---|---|---|---|---|---|---|---|
Median | IQR | Median | IQR | Median | IQR | Median | IQR | ||
All Patients | ADC p50 | 2.043 | 0.935 | 1.205* | 0.412 | 1.304* | 0.284 | 1.152* | 0.222 |
ADC p10 | 1.297 | 0.510 | 0.828* | 0.241 | 0.913* | 0.190 | 0.822* | 0.274 | |
ASL-CBF p50 | 31.00 | 4.000 | 52.00* | 26.25 | 33.00† | 8.000 | 33.50† | 14.00 | |
ASL-CBF p90 | 43.00 | 6.500 | 71.50* | 40.00 | 53.00† | 10.00 | 52.00† | 16.00 | |
DSCrCBF p50 | 1.349 | 0.877 | 2.152* | 0.972 | 1.662† | 0.512 | 1.933 | 1.512 | |
DSCrCBF p90 | 2.890 | 1.656 | 4.071* | 1.623 | 3.484† | 0.809 | 4.092 | 1.923 | |
DSCrCBV p50 | 1.427 | 0.546 | 2.127* | 0.738 | 1.634† | 0.575 | 1.929 | 1.041 | |
DSCrCBV p90 | 2.930 | 1.147 | 4.000* | 1.527 | 3.159† | 0.801 | 3.932 | 2.112 | |
Pseudoprogression Patients | ADC p50 | 1.842 | 0.602 | 1.373* | 0.407 | 1.359* | 0.382 | 1.232* | 0.245 |
ADC p10 | 1.251 | 0.504 | 0.914* | 0.270 | 0.913* | 0.166 | 0.897* | 0.177 | |
ASL-CBF p50 | 31.00 | 2.000 | 57.00* | 28.00 | 32.00†‡ | 2.249 | 32.50† | 14.75 | |
ASL-CBF p90 | 43.00 | 6.502 | 93.00*‡ | 40.40 | 46.70†‡ | 5.000 | 51.00† | 18.48 | |
DSCrCBF p50 | 1.369 | 0.386 | 2.299* | 1.263 | 1.473† | 0.528 | 1.473† | 0.960 | |
DSCrCBF p90 | 2.890 | 1.902 | 3.988 | 1.810 | 3.571 | 0.503 | 3.516 | 1.425 | |
DSCrCBV p50 | 1.495 | 0.503 | 2.127 | 0.890 | 1.605† | 0.851 | 1.573† | 0.949 | |
DSCrCBV p90 | 2.948 | 1.172 | 4.384* | 2.015 | 3.393† | 0.805 | 3.393 | 1.080 | |
Control Patients | ADC p50 | 1.604 | 1.005 | 1.155* | 0.261 | 1.245* | 0.145 | 1.061*§ | 0.196 |
ADC p10 | 1.159 | 0.500 | 0.811* | 0.103 | 0.916* | 0.174 | 0.760* | 0.237 | |
ASL-CBF p50 | 31.00 | 4.500 | 43.00* | 20.00 | 39.00*‡ | 7.000 | 37.00 | 13.00 | |
ASL-CBF p90 | 43.50 | 5.501 | 61.00*‡ | 20.00 | 56.00*‡ | 5.001 | 57.00* | 10.00 | |
DSCrCBF p50 | 1.139 | 0.743 | 2.129* | 0.673 | 1.716† | 0.524 | 2.957*§ | 1.204 | |
DSCrCBF p90 | 2.704 | 1.445 | 4.071* | 1.271 | 2.896† | 0.660 | 4.332*§ | 1.162 | |
DSCrCBV p50 | 1.269 | 0.601 | 1.972* | 0.622 | 1.663† | 0.521 | 2.563*§ | 0.897 | |
DSCrCBV p90 | 2.979 | 1.106 | 3.932* | 1.015 | 3.027† | 0.745 | 4.802*§ | 1.203 |
Abbreviations: IQR, interquartile range; ADC, apparent diffusion coefficient (in µm2/ms); ASL-CBF, arterial spin labeling estimated blood flow (in mL/100 g of tissue per minute); DSCrCBF, relative blood flow and DSCrCBV, relative blood volume (both estimated by DSC perfusion); p10, p50, and p90 correspond to the 10th, 50th, and 90th percentile values; * value significantly different from baseline; † value significantly different from after RT; § value significantly different from “progression”; and ‡ significant difference between group 1 and 2 values.