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. 2018 Mar 5;21(6):603–615. doi: 10.1093/ijnp/pyy022

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© The Author(s) 2018. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — The number of synapses including subtypes of synapse in CA1 (*P <.05; **P <.01; ***P<.001) (∆: vehicle group; ▲: vortioxetine; ▽: fluoxetine). (A) The total number of synapses was significantly higher in the vortioxetine group compared with the vehicle and fluoxetine groups. (B) The number of nonperforated spine synapses was significantly higher in vortioxetine group compared with the vehicle and fluoxetine groups. (C) The number of perforated spine synapses was significantly higher in the vortioxetine group compared with the vehicle and fluoxetine groups. (D) The number of shaft synapses was not any different in the vortioxetine group compared with the vehicle and fluoxetine groups.