Table 2.

Association^a Between rSO₂ and Death and Clinical Outcomes

	Per 5% Increase in rSO2		rSO2 < 30% vs rSO2 ≥ 30%
Outcome	Odds Ratio (95% CI)	P Value	Odds Ratio (95% CI)	P Value
Death within 14 d	0.72 (0.56 to 0.93)	.01	3.13 (1.20 to 8.11)	.02
Death within 14 d, adjustedb	0.48 (0.29 to 0.77)	.003	5.79 (1.54 to 21.80)	.009
Death within 30 d	0.73 (0.58 to 0.91)	.005	3.42 (1.46 to 8.00)	.005
Death within 30 d, adjustedb	0.65 (0.45 to 0.93)	.02	3.96 (1.19 to 13.15)	.02
Clinical parametersc
CSF opening pressure > 250 mm H2O	0.88 (0.69 to 1.11)	.28	1.26 (0.41 to 3.87)	.68
Pulse oximetry < 94% sa02	0.93 (0.66 to 1.33)	.70	1.47 (0.33 to 6.57)	.61
Mean arterial pressure < 84 mmhg	0.86 (0.66 to 1.12)	.25	1.53 (0.51 to 4.60)	.45
Glasgow Coma Scale < 15	0.98 (0.83 to 1.16)	.80	0.84 (0.38 to 1.85)	.67

Abbreviations: CI, confidence interval; CSF, cerebrospinal fluid; rSO₂ = regional cerebral tissue oxygenation.

^aUnadjusted logistic regression models using the first rSO₂ measurement in days 1–14.

^bModels adjusted for Glasgow Coma Scale <15, CSF white cells >5 cells/μL, CSF quantitative culture, temperature, and anemia (<11 g/dL for men, <10.5 g/dL for women).

^cClinical outcomes on or after the rSO₂ measurement.