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Blood plasma concentrations of lithium and valproic acid (VPA) treatment drugs. Plasma concentrations of lithium and VPA measured 5 hours after administration in (A) lithium-treated rats and (B) VPA-treated rats. Lower limit of the therapeutic concentration range is shown by red dotted line. Rat 2 in the VPA-treated rats (circled in red) showed symptoms of toxicity including very high plasma concentrations and therefore was not used in further analyses.
