Table 4.
Prevalence of lacunes in population-based studies
| Study | Population | Number | Age (yr) | MRI parameters |
Lacune (%) | |
|---|---|---|---|---|---|---|
| Sequence | Field strength (Tesla) | |||||
| CHS (1997) [14] | USA | 3,397 | 75±7 | T1, T2, PD | 1.5 | 28 |
| RSS (2002) [15]* | Netherlands | 1,077 | 72±7 | T1, T2, PD | 1.5 | 20 |
| NILS-LSA (2003) [16]* | Japan | 1,721 | 59±11 | T1, T2 | 1.5 | 10 |
| FHS (2005) [17]* | USA | 2,081 | 62±10 | PD-T2, T2, PD | 1.5 | 12 |
| ASPS (2006) [18] | Austria | 505 | 64±6 | T1, T2, PD | 1.5 | 8 |
| 3C-Dijon Study (2012) [11]* | France | 1,841 | 72±4 | 3DT1, T2, PD | 1.5 | 9 |
| EDIS (2017) [2] | Singapore | 832 | 70±6 | 3DT1, T2, FLAIR | 3.0 | 17.2 |
| RISK (2017) [2] | Hong Kong | 850 | 71±5 | 3DT1, T2, FLAIR | 3.0 | 32.6 |
| OBAMA (2017) [2] | Korea | 115 | 65±5 | 3DT1, T2, FLAIR | 3.0 | 19.1 |
| Shunyi Study (2017) | China | 1,211 | 56±9 | 3DT1, T2, FLAIR | 3.0 | 14.5 |
Values are presented as mean±SD.
MRI, magnetic resonance imaging; CHS, Cardiovascular Health Study; PD, proton density; RSS, Rotterdam Scan Study; NILS-LSA, National Institute for Longevity Sciences-Longitudinal Study of Aging; FHS, Framingham Heart Study; ASPS, Austrian Stroke Prevention Study; 3D, three-dimensional; EDIS, Epidemiology of Dementia in Singapore study; FLAIR, fluid-attenuated inversion recovery; RISK, Risk Index for Subclinical brain lesions in Hong Kong study; OBAMA, Oligomeric Beta Amyloid detection by Multimer detection system in Alzheimer’s disease study.
*
Reported silent brain infarction.