Table 1.
Baseline characteristics according to susceptibility vessel sign on magnetic resonance imaging in the ASTER trial
| Characteristic | SVS (–) (n=59) | SVS (+) (n=143) | P | ASD (%) |
|---|---|---|---|---|
| Demographics | ||||
| Age (yr) | 67.6±13.7 | 67.8±16.0 | 0.94 | 1.1 |
| Men | 26/59 (44.1) | 82/143 (42.7) | 0.085 | 26.8 |
| Medical history | ||||
| Hypertension | 38/59 (64.4) | 78/139 (56.1) | 0.28 | 17.0 |
| Diabetes | 14/59 (23.7) | 21/141 (14.9) | 0.13 | 22.5 |
| Hypercholesterolemia | 21/59 (35.6) | 53/139 (38.1) | 0.74 | 5.3 |
| Current smoking | 11/51 (21.6) | 32/119 (26.9) | 0.46 | 12.5 |
| Coronary artery disease | 10/59 (17.0) | 18/138 (13.0) | 0.47 | 11.0 |
| Previous stroke or TIA | 11/58 (18.6) | 22/142 (15.5) | 0.58 | 8.4 |
| Previous antithrombotic medications | 29/58 (50.0) | 60/140 (42.9) | 0.36 | 14.4 |
| Antiplatelet | 17/58 (29.3) | 42/140 (30.0) | 0.92 | 1.5 |
| Anticoagulant | 14/58 (24.1) | 20/140 (14.3) | 0.094 | 25.2 |
| Current stroke event | ||||
| Systolic blood pressure (mm Hg) | 149±28 | 146±23 | 0.34 | 14.4 |
| NIHSS score* | 15.9±6.2 | 15.4±6.4 | 0.57 | 8.9 |
| Pre-stroke mRS ≥1 | 12/59 (20.3) | 18/143 (12.6) | 0.16 | 21.0 |
| ASPECTS* | 7 (5–8) | 7 (5–8) | 0.63 | 7.4 |
| Site of occlusion | ||||
| M1-MCA | 45/59 (76.3) | 100/143 (69.9) | 0.36 | 14.3 |
| M2-MCA | 14/59 (23.7) | 43/143 (30.1) | ||
| Favorable collaterals (ASITN 3/4) | 14/52 (26.9) | 29/126 (23.0) | 0.58 | 9.0 |
| Suspected stroke cause | ||||
| Large artery atherosclerosis | 6/59 (10.2) | 15/143 (10.5) | 1.00 | 1.3 |
| Cardioembolic | 23/59 (39.0) | 55/143 (38.5) | ||
| Other or unknown | 30/59 (50.9) | 73/143 (51.1) | ||
| Intravenous rt-PA | 30/59 (50.9) | 102/143 (71.3) | 0.005 | 43.0 |
| Endovascular treatment | ||||
| First-line CA strategy | 28/59 (47.5) | 68/143 (47.6) | 0.99 | 0.0 |
| General anesthesia | 10/59 (17.0) | 15/143 (10.5) | 0.20 | 18.9 |
| Onset to groin puncture time (min)† | 235 (159–295) | 220 (180–270) | 0.36 | 13.9 |
| Onset to imaging† | 108 (72–154) | 109 (82–143) | 0.70 | 5.9 |
| Imaging to groin puncture | 1115 (65–151) | 106 (63–142) | 0.25 | 17.6 |
Values are presented as mean±standard deviation, number/total number (%), or median (interquartile range).
ASTER, Aspiration vs. Stent Retriever for Successful Revascularization; SVS, susceptibility vessel sign; ASD, absolute standardized difference; TIA, transient ischemic attack; NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin scale; ASPECTS, Alberta Stroke Program Early Computed Tomography Score; MCA, middle cerebral artery; ASITN, American Society of Interventional and Therapeutic Neuroradiology; rt-PA, recombinant tissue plasminogen activator; CA, contact aspiration.
*
2 missing values;
†
1 missing value.