Figure 7.

BDNF/TrkB signaling modulates Munc18-1, pMunc18-1, nPKCε, and pnPKCε levels under synaptic activity conditions. (A) Representative Western blot bands and quantification show that after the treatment with BDNF, the ratio of pMunc18-1/Munc18-1 significantly decreases while after the 47/TrkB treatment, it significantly increases. (B) Representative Western blot bands and quantification show that after the 47/TrkB treatment, pnPKCε significantly increases without affecting nPKCε levels. In accordance, the ratio is significantly increased. Data are mean percentage ± SEM, ^*p < 0.05 (n = 5).