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. 2018 Apr 30;46(10):5097–5108. doi: 10.1093/nar/gky275

Figure 2.

Figure 2.

An array CGH analysis of an intra-chromosomal product. (A) DNA from colony #17 was co-hybridized with DNA from the parental strain, LS20, to a S. cerevisiae CGH microarray. Genome-wide overview (top) and the enlarged chrVI (bottom) are shown. The FRFR structure is flanked by copy number gains and telomeric deletion. Note that TRP1 gene is deleted in the parental strain, LS20, so that no peak for the trp1d gene was detected. (B) A potential hairpin structure for chromatid fusion in BFB cycle. The dicentric chromosome is illustrated based on the array CGH profile. The 200 bp region around the boundary (red dotted line) contains a palindromic pair of sequences, which could form a hairpin structure (Tm = 32.2°C) after resection of the DSB end. The hairpin capped end and next round of DNA replication form a dicentric chromosome with copy number gain.