Table 3.

Predictive value of 2HG detection by MRS using MEGA-PRESS and optimized PRESS sequences

CRLB Cutoff, %	Sensitivity, %		Specificity, %		PPV, %		NPV, %
	MEGA-PRESS	PRESS	MEGA-PRESS	PRESS	MEGA-PRESS	PRESS	MEGA-PRESS	PRESS
20	60	72	100	100	100	100	33	44
30	90	72	100	75	100	93	67	37
50	95	83	100	75	100	94	80	50
999	100	100	100	25	100	86	100	100

Sensitivity, specificity, PPV, and NPV were calculated for MEGA-PRESS and optimized PRESS in a prospective cohort of 24 subjects scanned before surgery, with different CRLB cutoffs.