Table 5. Association between the prognostic role of mRNA expression of NK receptor ligands and p53 status.
| RFS | OS | ||||
|---|---|---|---|---|---|
| Ligand | Wild-type | Mutated | Wild-type | Mutated | |
| NK-activating ligands | AICL HR (95%CI) p-value |
0.50 (0.32–0.78) 0.042 |
0.51 (0.31–0.83) 0.016 |
0.42 (0.22–0.81) 0.068 |
0.44 (0.2–0.94) 0.073 |
| B7-1 HR (95%CI) p-value |
0.66 (0.27–1.66) 0.38 |
0.37 (0.20–0.66) 0.0026 |
N/A N/A |
0.29 (0.07–1.16) 0.14 |
|
| B7-2 HR (95%CI) p-value |
1.35 (0.85–2.13) 0.26 |
0.46 (0.28–0.77) 0.0092 |
0.65 (0.33–1.30) 0.24 |
0.37 (0.17–0.79) 0.028 |
|
| BAT3 HR (95%CI) p-value |
1.27 (0.81–1.98) 0.35 |
0.63 (0.36–1.11) 0.15 |
0.60 (0.31–1.14) 0.23 |
2.06 (0.71–5.96) 0.23 |
|
| CD27 HR (95%CI) p-value |
0.71 (0.45–1.12) 0.23 |
0.39 (0.24–0.65) 0.0012 |
0.67 (0.35–1.28) 0.24 |
0.29 (0.13–0.61) 0.0081 |
|
| CD48 HR (95%CI) p-value |
0.55 (0.36–0.84) 0.042 |
0.52 (0.31–0.85) 0.019 |
0.63 (0.32–1.24) 0.24 |
0.32 (0.15–0.69) 0.011 |
|
| CD58 HR (95%CI) p-value |
0.55 (0.36-0.85) 0.042 |
0.66 (0.4-1.09) 0.14 |
0.48 (0.25-0.92) 0.11 |
0.5 (0.22-1.12) 0.15 |
|
| CD70 HR (95%CI) p-value |
1.41 (0.84–2.38) 0.26 |
0.76 (0.46–1.25) 0.29 |
1.65 (0.84–3.24) 0.24 |
0.51 (0.24–1.10) 0.15 |
|
| CD72 HR (95%CI) p-value |
0.81 (0.52–1.26) 0.37 |
0.35 (0.18–0.69) 0.0064 |
1.53 (0.80–2.92) 0.24 |
0.29 (0.14–0.63) 0.0081 |
|
| KMT2E HR (95%CI) p-value |
2.05 (0.87–4.8) 0.22 |
0.7 (0.38–1.31) 0.28 |
N/A N/A |
1.66 (0.44–6.18) 0.45 |
|
| MICA HR (95%CI) p-value |
0.59 (0.39–0.90) 0.048 |
1.33 (0.83–2.15) 0.26 |
0.55 (0.28–1.08) 0.19 |
2.76 (1.21–6.32) 0.038 |
|
| MICB HR (95%CI) p-value |
0.55 (0.35–0.86) 0.042 |
0.55 (0.33–0.91) 0.033 |
0.41 (0.21–0.82) 0.068 |
0.52 (0.23–1.17) 0.17 |
|
| NECL2 HR (95%CI) p-value |
0.62 (0.38–1.01) 0.16 |
1.26 (0.78–2.02) 0.35 |
0.47 (0.24–0.92) 0.11 |
0.71 (0.33–1.53) 0.39 |
|
| SLAMF6 HR (95%CI) p-value |
2.01 (0.73–5.52) 0.25 |
0.36 (0.17–0.74) 0.012 |
N/A N/A |
2.01 (0.54–7.49) 0.34 |
|
| SLAMF7 HR (95%CI) p-value |
0.54 (0.20–1.47) 0.28 |
0.22 (0.11–0.45) 0.000088 |
N/A N/A |
0.19 (0.05–0.72) 0.025 |
|
| TNFSF9 HR (95%CI) p-value |
1.74 (1.01–2.99) 0.15 |
1.20 (0.71–2.03) 0.5 |
1.82 (0.76–4.36) 0.24 |
0.64 (0.26–1.54) 0.35 |
|
| ULBP1 HR (95%CI) p-value |
0.64 (0.40–1.03) 0.19 |
1.64 (0.95–2.84) 0.12 |
0.62 (0.32–1.19) 0.24 |
1.96 (0.91–4.25) 0.15 |
|
| ULBP2 HR (95%CI) p-value |
1.99 (0.81–4.92) 0.23 |
2.29 (1.27–4.12) 0.013 |
N/A N/A |
17.36 (2.17–139.12) 0.0073 |
|
| ULBP3 HR (95%CI) p-value |
5.76 (1.34–24.78) 0.042 |
0.64 (0.33–1.22) 0.21 |
N/A N/A |
1.66 (0.43–6.38) 0.45 |
|
| ULBP4 HR (95%CI) p-value |
3.19 (0.75–13.66) 0.22 |
0.61 (0.31–1.20) 0.2 |
N/A N/A |
0.25 (0.03–2.04) 0.23 |
|
| VIM HR (95%CI) p-value |
0.71 (0.46–1.10) 0.23 |
1.5 (0.81–2.80) 0.24 |
0.52 (0.27–1.00) 0.13 |
0.64 (0.29–1.41) 0.34 |
|
| NK-activating and inhibitory ligands | HLA-C HR (95%CI) p-value |
0.78 (0.50–1.23) 0.35 |
0.47 (0.29–0.76) 0.0064 |
0.64 (0.33–1.22) 0.24 |
0.33 (0.15–0.73) 0.017 |
| HLA-E HR (95%CI) p-value |
0.56 (0.36–0.85) 0.042 |
0.40 (0.24–0.67) 0.0019 |
0.49 (0.25–0.96) 0.13 |
0.32 (0.15–0.68) 0.011 |
|
| NECL5 HR (95%CI) p-value |
0.80 (0.49–1.28) 0.37 |
1.75 (0.92–3.33) 0.13 |
0.49 (0.24–1.01) 0.13 |
1.58 (0.71–3.51) 0.34 |
|
| NECTIN2 HR (95%CI) p-value |
0.73 (0.48–1.11) 0.23 |
0.72 (0.42–1.23) 0.26 |
1.69 (0.86–3.34) 0.24 |
1.58 (0.68–3.68) 0.34 |
|
| NK-inhibitory ligands | CEACAM1 HR (95%CI) p-value |
1.37 (0.88–2.14) 0.25 |
0.53 (0.31–0.90) 0.033 |
1.57 (0.76–3.24) 0.24 |
0.52 (0.24–1.13) 0.15 |
| CLEC2D HR (95%CI) p-value |
2.31 (0.90–5.91) 0.19 |
0.43 (0.19–0.96) 0.0604 |
N/A N/A |
4.87 (1.01–23.45) 0.073 |
|
| COL3A1 HR (95%CI) p-value |
0.57 (0.37–0.88) 0.045 |
1.69 (0.9–3.15) 0.14 |
0.32 (0.16–0.62) 0.0078 |
0.53 (0.21–1.33) 0.23 |
|
| HLA-A HR (95%CI) p-value |
1.21 (0.79–1.88) 0.38 |
0.56 (0.34–0.90) 0.033 |
0.74 (0.37–1.50) 0.4 |
0.52 (0.24–1.13) 0.15 |
|
| HLA-B HR (95%CI) p-value |
0.75 (0.49–1.15) 0.26 |
0.40 (0.25–0.65) 0.00106 |
0.57 (0.30–1.12) 0.22 |
0.32 (0.15–0.68) 0.011 |
|
| PDL1 HR (95%CI) p-value |
0.45 (0.15–1.33) 0.23 |
0.20 (0.11–0.37) 0.00000064 |
N/A N/A |
0.22 (0.06–0.82) 0.0407 |
|
| PDL2 HR (95%CI) p-value |
0.79 (0.49–1.28) 0.37 |
0.56 (0.35–0.91) 0.033 |
0.73 (0.38–1.40) 0.36 |
0.61 (0.23–1.64) 0.35 |
|