Table 1.

L1-ORF2 modulates survival signaling – AKT array. ORF2-overexpressed and control cell lysates were analyzed for changes in survival signaling using AKT array. Protein phosphorylation and total levels were noted as arbitrary absorbance units and their ratio was calculated. Proteins showing greater than the 3-fold decrease in phosphorylation levels were listed along with their site and the potential kinase associated.

Phosphorylation site	Ratio (phospho/total protein)		Amino acid sequence	Kinase involved	Biological effects/references
	ORF2	Control
AFX/FoxO4 (Phospho-Ser197)	0.27	0.92	RRRAApSMDSS	Akt	Cell survival [25]
ASK1 (Phospho-Ser83)	0.16	0.72	RGRGSpSVGGG	Akt	Cell survival [26]
ASK1 (Phospho-Ser966)	0.16	0.66	YLRSIpSLPVP	Unknown	Cell survival [26]
BAD (Phospho-Ser112)	0.18	0.55	RSRHSpSYPAG	p90RSK, PKA	Cell survival [27]
BAD (Phospho-Ser136)	0.07	0.65	RGRSRpSAPPN	Akt	Cell survival [28]
BAD (Phospho-Ser155)	0.04	0. 58	ELRRMpSDEFV	PKA	Cell survival [25,27,28]
BCL-2 (Phospho-Ser70)	0.06	0.64	PVARTpSPLQT	IL3, JNK	Cell survival [28,29]
BCL-2 (Phospho-Thr56)	0.66	0.54	SQPGHpTPHPA	Unknown	Cell survival [29]
BCL-XL (Phospho-Ser62)	0.18	0.92	WHLADpSPAVN	JNK	Cell survival [29]
c-Jun (Phospho-Ser63)	0.08	0.58	SDLLTpSPDVG	Unknown	Cell survival [30]
FKHR/FoxO1 (Phospho-Ser319)	0.28	0.74	RPRTSpSNAST	Akt	Cell survival [25,31]
FKHRL1/FoxO3a (Phospho-Ser253)	0.15	0.74	RRRAVpSMDNS	Akt	Cell survival [32]
GSK3b (Phospho-Ser9)	0.11	0.68	RPRTTpSFAES	Akt	Cell survival [33,34]