Figure 2.

Objective chemotherapy-induced peripheral neuropathy (CIPN) events at a cumulative dose of 960 mg/m². A) The efficacy of cryotherapy for reducing the primary end point, incidence of CIPN, was assessed by tactile-sensory deficits on the monofilament test. Any tactile deterioration from the pretreatment baseline in an intervention or control side hand or foot at a cumulative dose of 960 mg/m² was considered a CIPN event. The differential incidence between the intervention and control sides was evaluated using a two-sided McNemar’s test (n = 36). B) Treatment with cryotherapy reduced thermosensory dysfunction. Only patients who exhibited a normal sensory threshold at baseline were included (hand: warm, n = 34, cold, n = 36; foot: warm, n = 33, cold, n = 32). Any response delay, response reduction, or thermal analgesia at a cumulative dose of 960 mg/ m² was considered a CIPN. C) This figure shows manipulative dexterity deficits. P values were determined by a two-sided paired t test between the intervention and control side. The solid line denotes the intervention side, and the dotted line indicates the control side (N = 36).