Figure 3.

Severity of subjective symptoms (at a cumulative dose of 960 mg/m²). The administration of cryotherapy also reduced the subjective symptoms based on the Patient Neuropathy Questionnaire responses (the secondary end point, subjective) at a cumulative dose of 960 mg/m² (P values determined by the McNemar’s test, n = 36). The subjective responses to each item were graded from A (no neuropathy) to E (severe neuropathy) by the patient. A rank of D or E indicates impaired activities of daily living. *Activities of daily living were interfered with.