Figure 4.

The appearance of severe subjective neuropathy symptoms with cumulative dose. Severe subjective neuropathy symptoms (Patient Neuropathy Questionnaire ≥ D; moderate to severe tingling, pain, or numbness that interferes with activities of daily living) with cumulative dose were compared between the intervention and control sides using a log-rank test (n = 40). The solid line denotes the intervention side, and the dotted line indicates the control side. The dotted vertical line represents a cumulative dose of 960 mg/m². We included four censored patients who did not complete cumulative dose of 960 mg/m² paclitaxel due to pneumonia (n = 1), severe fatigue (n = 1), severe liver dysfunction (n = 1), and macular edema (n = 1). A two-sided log-rank test was used to calculate the P values.