Table 2.
Cox regression results on TCGA glioma survival (pooled results, multiply imputed 100x)
| Base | |||||
|---|---|---|---|---|---|
| Variable | Beta Coeff | SE | 95% CI | P | |
| Age at diagnosis | 0.05 | 0.01 | [0.03, 0.06] | 4.08E-09 | * |
| Sex (male) | 0.35 | 0.18 | [−0.01, 0.7] | 5.50E-02 | |
| IDH-mut 1p/19q status (IDH-mut-non-codel) | 0.73 | 0.32 | [0.1, 1.35] | 2.31E-02 | * |
| IDH-mut 1p/19q status (IDH-wt) | 1.64 | 0.37 | [0.91, 2.37] | 9.57E-06 | * |
| KPS | −0.01 | 0.01 | [−0.03, 0.01] | 2.21E-01 | |
| MGMT promoter (unmethylated) | −0.01 | 0.21 | [−0.43, 0.41] | 9.75E-01 | |
| Grade II | −1.04 | 0.33 | [−1.69, −0.39] | 1.65E-03 | * |
| Grade III | −0.31 | 0.24 | [−0.77, 0.15] | 1.88E-01 | |
| Base + epiTOC | |||||
| Variable | Beta Coeff | SE | 95% CI | P | |
| Age at diagnosis | 0.05 | 0.01 | [0.04, 0.07] | 5.86E-10 | * |
| epiTOC | −3.85 | 1.72 | [−7.22, −0.49] | 2.48E-02 | * |
| Sex (male) | 0.32 | 0.18 | [−0.03, 0.67] | 7.67E-02 | |
| IDH-mut 1p/19q status (IDH-mut-non-codel) | 0.50 | 0.33 | [−0.15, 1.15] | 1.34E-01 | |
| IDH-mut 1p/19q status (IDH-wt) | 1.47 | 0.38 | [0.72, 2.21] | 1.24E-04 | * |
| KPS | −0.01 | 0.01 | [−0.03, 0.01] | 1.79E-01 | |
| MGMT promoter (unmethylated) | −0.08 | 0.22 | [−0.5, 0.35] | 7.23E-01 | |
| Grade II | −1.21 | 0.34 | [−1.88, −0.55] | 3.41E-04 | * |
| Grade III | −0.42 | 0.24 | [−0.89, 0.05] | 7.83E-02 | |
| Base + Horvath’s Clock | |||||
| Variable | Beta Coeff | SE | 95% CI | P | |
| Age at diagnosis | 0.06 | 0.01 | [0.05, 0.08] | 3.91E-12 | * |
| Sex (male) | 0.28 | 0.18 | [−0.08, 0.63] | 1.24E-01 | |
| Horvath age | −0.01 | 0.00 | [−0.02, −0.01] | 2.68E-04 | * |
| IDH-mut 1p/19q status (IDH-mut-non-codel) | 0.35 | 0.33 | [−0.31, 1] | 3.00E-01 | |
| IDH-mut 1p/19q status (IDH-wt) | 1.07 | 0.40 | [0.29, 1.85] | 7.20E-03 | * |
| KPS | −0.01 | 0.01 | [−0.03, 0.01] | 1.58E-01 | |
| MGMT promoter (unmethylated) | −0.04 | 0.21 | [−0.46, 0.38] | 8.42E-01 | |
| Grade II | −1.24 | 0.33 | [−1.89, −0.58] | 2.14E-04 | * |
| Grade III | −0.42 | 0.24 | [−0.89, 0.04] | 7.55E-02 | |
| Base + epiTOC + Horvath’s Clock | |||||
| Variable | Beta Coeff | SE | 95% CI | P | |
| Age at diagnosis | 0.07 | 0.01 | [0.05, 0.08] | 7.88E-12 | * |
| epiTOC | 0.87 | 2.33 | [−3.69, 5.43] | 7.08E-01 | |
| Sex (male) | 0.28 | 0.18 | [−0.08, 0.63] | 1.23E-01 | |
| Horvath age | −0.02 | 0.01 | [−0.03, −0.01] | 3.46E-03 | * |
| IDH-mut 1p/19q status (IDH-mut-non-codel) | 0.36 | 0.34 | [−0.3, 1.02] | 2.82E-01 | |
| IDH-mut 1p/19q status (IDH-wt) | 1.06 | 0.40 | [0.28, 1.84] | 8.04E-03 | * |
| KPS | −0.01 | 0.01 | [−0.03, 0.01] | 1.62E-01 | |
| MGMT promoter (unmethylated) | −0.03 | 0.22 | [−0.45, 0.39] | 8.87E-01 | |
| Grade II | −1.22 | 0.34 | [−1.88, −0.56] | 3.02E-04 | * |
| Grade III | −0.41 | 0.24 | [−0.88, 0.06] | 8.74E-02 | |
N = 580, deaths = 149.
Seventy-seven observations deleted due to missingness (12 missing IDH information, 66 missing survival information).
Reference groups: Sex (female), IDH-mut 1p/19q status (IDH-mut-codel), MGMT promoter (methylated), grade (IV).
*P-value < .05.