Table 1. .
Associations of Baseline Biomarker Levels and Small Arterial Elasticity Evaluated via Linear Regression
| Univariable Models | Multivariable Model,a Markers Studied Individually | Multivariable Model,a Markers Studied Simultaneously | ||||
|---|---|---|---|---|---|---|
| Biomarker, log2 | ß (SE) | P Value | ß (SE) | P Value | ß (SE) | P Value |
| D-dimer, µg/mL | –0.99 (0.19) | <.001 | –0.07 (0.20) | .74 | 0.18 (0.21) | .40 |
| hsCRP, µg/mL | –0.18 (0.09) | .04 | –0.18 (0.08) | .03 | –0.08 (0.13) | .51 |
| IL-6, pg/mL | –0.49 (0.18) | .006 | –0.56 (0.16) | <.001 | –0.52 (0.18) | .003 |
| SAA, µg/mL | –0.14 (0.11) | .21 | –0.13 (0.09) | .18 | 0.07 (0.14) | .63 |
| IL-27, pg/mL | 0.04 (0.10) | .66 | –0.06 (0.09) | .49 | –0.04 (0.09) | .61 |
| sICAM-1, µg/mL | –0.59 (0.29) | .05 | –0.45 (0.26) | .09 | –0.70 (0.42) | .10 |
| sVCAM-1, µg/mL | 0.07 (0.31) | .82 | –0.14 (0.28) | .63 | 0.57 (0.44) | .20 |
Regression coefficient (ß) estimates the difference in small arterial elasticity per log2-unit increment in (or 2-fold higher) biomarker level.
Abbreviations: hsCRP, high-sensitivity C-reactive protein; IL-6, interleukin-6; IL-27, interleukin-27; SAA, serum amyloid A; SE, standard error of ß estimate; sICAM-1, soluble intercellular adhesion molecule–1; sVCAM-1, soluble vascular adhesion molecule–1.
aAdjusted for sex at birth, age, race/ethnicity, CD4+ count, HIV viral load, smoking, hypertension (systolic BP ≥140 mmHg, diastolic BP ≥90 mmHg, or use of BP-lowering therapy), body mass index, high-density lipoprotein cholesterol, and total cholesterol.