Figure 6.

Associations between transgenic eqIL-1Ra expression and joint pathology in the OCF model. (a) Plots of total MRI score in the OCF joints of the treated horses at week 0 versus (left) synovial fluid eqIL-1Ra levels at week 2, and (right) eqIL-1Ra levels averaged from weeks 2–12. For both plots, the arrow designates the data point from one horse with unusually high eqIL-1Ra expression at week 2 relative to the other nine animals (see Fig. 1c). The solid lines show the best-fit line plots for the data points of all 10 animals. The dashed lines show the best-fit line plots calculated without the outlying data point. Pearson correlation coefficients (r) for MRI score and eqIL-1Ra levels both with (all) and excluding the outlying data point (9/10) are shown. (b) Plot of total MRI scores at week 0 versus total MRI score at week 12 for the OCF joints of each horse in the treated (gray) and control (black) groups. The solid lines show the respective best-fit line plots for each group. The corresponding line equations and Pearson correlation coefficients (r) are also shown as indicated. *p < 0.05.