Fig 2.

Restricted cubic splines for the association between average lifetime alcohol intake and overall mortality (A, 4 knots), cardiovascular-related mortality (5 knots), cancer-related mortality (C, linear), total cancer risk (D, linear), risk of alcohol-related cancers (E, linear), and risk of cancer or death (F, 4 knots/3 splines) in men and women combined. Results are adjusted for gender, study centre, race, BMI, randomisation group, smoking status, year of DHQ completion, marital status, educational attainment, family history of cancer, HRT use (women only), energy intake, red meat intakes per 1,000 kcal, processed meat intakes per 1,000 kcal, coffee intake, fruit and vegetable intake, fibre intake, and calcium intake). Akaike's information criterion and likelihood ratio tests were used to investigate if there was a significant improvement to the model fit when fitting restricted cubic spline models, with varying number of knots, compared to a linear model with average lifetime alcohol intake as a continuous variable. BMI, body mass index; DHQ, Diet History Questionnaire; HRT, hormone replacement therapy.