Table 3.
Top 15 gene transcripts differentially expressed between APM and TKA meniscus
| Gene symbol | Gene name | Fold change | adjusted P value |
|---|---|---|---|
| Gene transcripts elevated in TKA meniscus | |||
| CSN1S1 | casein alpha S1 | 6.31 | 0.009 |
| COL10A1 | collagen type X alpha 1 chain | 5.87 | 0.029 |
| WIF1 | WNT inhibitory factor 1 | 5.65 | 0.039 |
| SPARCL1 | SPARC like 1 | 5.19 | 0.029 |
| TSPAN7 | tetraspanin 7 | 4.88 | 0.009 |
| DEFA3 | defensin alpha 3 | 4.59 | 0.030 |
| SEPP1 | selenoprotein P, plasma, 1 | 4.32 | 0.039 |
| PLA2G2A | phospholipase A2 group IIA | 4.13 | 0.034 |
| RGS5 | regulator of G-protein signaling 5 | 4.09 | 0.009 |
| ABCC9 | ATP binding cassette subfamily C member 9 | 4.08 | 0.019 |
| MMP9 | matrix metallopeptidase 9 | 4.03 | 0.042 |
| CFD | complement factor D | 3.98 | 0.018 |
| IGF2 | insulin like growth factor 2 | 3.78 | 0.040 |
| APOE | apolipoprotein E | 3.77 | 0.029 |
| OLFML2A | olfactomedin like 2A | 3.77 | 0.009 |
| Gene transcripts repressed in TKA meniscus | |||
| POSTN | periostin | −8.33 | 0.042 |
| VEGFA | vascular endothelial growth factor A | −8.16 | 0.009 |
| CEMIP | cell migration inducing hyaluronan binding protein | −4.92 | 0.028 |
| COL6A3 | collagen type VI alpha 3 chain | −4.79 | 0.036 |
| SOX11 | SRY-box 11 | −4.74 | 0.041 |
| SGK2 | SGK2, serine/threonine kinase 2 | −4.60 | 0.041 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif 14 | −4.50 | 0.011 |
| MRI1 | methylthioribose-1-phosphate isomerase 1 | −4.23 | 0.027 |
| NARF | nuclear prelamin A recognition factor | −3.72 | 0.012 |
| KIAA0895L | KIAA0895 like | −3.64 | 0.049 |
| SLC17A9 | solute carrier family 17 member 9 | −3.63 | 0.009 |
| TNFRSF12A | TNF receptor superfamily member 12A | −3.53 | 0.030 |
| TYMS | thymidylate synthetase | −3.52 | 0.040 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | −3.43 | 0.032 |
| IGDCC4 | immunoglobulin superfamily DCC subclass member 4 | −3.37 | 0.013 |