Fig. 2.
(A) A comparison of DNA damage repair gene alterations found in high and low grade NMIBC. (B) Box and whisker plot comparing mutational burden per megabase between low-grade NMIBC (n = 23), high-grade NMIBC (n = 82), and MIBC (n = 40). (C) Box and whisker plot comparing mutational burden per megabase between high-grade NMIBC tumors with altered and unaltered DNA damage repair genes (n = 82).
DDR = DNA damage repair; MB = megabase; MIBC = muscle invasive bladder cancer; MSK-IMPACT = Memorial Sloan Kettering Cancer Center-Integrated Mutation Profiling of Actionable Cancer Targets; NMIBC = nonmuscle invasive bladder cancer.