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. Author manuscript; available in PMC: 2018 Jun 19.
Published in final edited form as: Biochemistry. 2018 Apr 17;57(18):2733–2743. doi: 10.1021/acs.biochem.8b00292

Figure 3. Membrane partition coefficients do not predict channel inhibition.

Figure 3

Numbers by each marker denote the analog identity. Shape and color of markers correspond to Figure 2. Values are from Table 1. Black arrows denote analogs with so low activity that we could not measure it (null response), with the marker indicating highest concentration tested. Brown and green arrows with dashed lines indicate modification of disulfide linker. Brown and green arrows with dotted lines indicate modification of aminoethyl groups.