Table 1.
Characteristics of Patients at Initial ICD Implantation and at the Time of ICD Replacement
| Initial Implantation (N = 231) | Generator Replacement (N = 231) | p Value | |
|---|---|---|---|
| Age, yrs | 65 ± 10 (66) | 70 ± 9 (70) | <0.01 |
|
| |||
| White race | 184 (80) | – | – |
|
| |||
| ICM | 159 (69) | – | – |
| NICM | 72 (31) | – | – |
|
| |||
| LVEF, % | 23 ± 6 (25) | 33 ± 14 (30) | <0.01 |
|
| |||
| CRT-D | 86 (37) | – | – |
|
| |||
| Comorbidities | |||
| Chronic kidney disease (stage III or greater) | 51 (22) | 68 (29) | <0.01 |
| Hypertension | 170 (74) | 189 (82) | <0.01 |
| Diabetes | 99 (43) | 107 (46) | <0.01 |
| Atrial fibrillation | 37 (16) | 56 (24) | <0.01 |
| History of stroke | 33 (14) | 37 (16) | 0.13 |
| Dialysis dependent | 1 (<1) | 2 (1) | 0.50 |
| Neoplastic disease | 6 (3) | 33 (14) | <0.01 |
| Cognitive impairment | 5 (2) | 9 (4) | 0.13 |
| Nursing facility resident | 1 (<1) | 2 (1) | 0.50 |
|
| |||
| Medication use | |||
| ACE inhibitor or ARB | 198 (86) | 194 (84) | 0.39 |
| Beta-blocker | 177 (77) | 200 (87) | <0.01 |
| Antiarrhythmic drug | 29 (13) | 37 (16) | 0.10 |
Values are mean ± SD (median) or n (%).
ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker; CRT-D = cardiac resynchronization therapy with a defibrillator; ICD = implantable cardioverter-defibrillator; ICM = ischemic cardiomyopathy; LVEF = left ventricular ejection fraction; NICM = nonischemic cardiomyopathy.