Table 1.
Demographic Characteristics and CSF Biomarker Profiles of Participants.
| N | Mean (SD) or % | |
|---|---|---|
| Characteristics | ||
|
| ||
| Age (Years) | 173 | 63.9 (7.1) |
| Gender (% Male) | 173 | 35% |
| Education (Years) | 173 | 16.3 (2.5) |
| MMSE (Total) | 173 | 29.2 (1.1) |
| APOE Status (% >= 1 E4 allele) | 173 | 36.40% |
| Family History of AD (% yes) | 173 | 70.50% |
|
| ||
| CSF AD Markers (pg/mL) | ||
|
| ||
| Aβ42 | 147 | 738.4 (201.5) |
| sAPP-β | 147 | 554.1 (202.6) |
| Phosphorylated Tau [P-tau] | 147 | 47.43 (18.1) |
|
| ||
| CSF Neuronal Integrity Markers (pg/mL) | ||
|
| ||
| Total Tau | 147 | 340.3 (168.5) |
| Neurofilament Light Chain [NFL] | 147 | 795.6 (636.0) |
|
| ||
| CSF Inflammatory Markers (pg/mL) | ||
|
| ||
| IL-6 | 167 | 1.1 (.5) |
| IL-8 | 173 | 42.4 (11.0) |
| IP-10 | 164 | 363.3 (210.0) |
| MCP-1 | 173 | 392.4 (102.7) |
| MIP-1β | 171 | 9.8 (3.3) |
|
| ||
| Plasma Inflammatory Markers (pg/mL) | ||
|
| ||
| IL-6 | 161 | 0.6 (.3) |
| IL-8 | 169 | 5.9 (2.0) |
| IP-10 | 163 | 393.7 (160.3) |
| MCP-1 | 171 | 222.2 (53.8) |
| MIP-1β | 168 | 55.3 (18.0) |